The Science
WHY DOSE MATTERS
Most prostate supplements list impressive-sounding ingredients in quantities too small to do anything. A label might say 'proprietary blend, 800mg' — but that 800mg could be split across 12 ingredients, leaving each at a fraction of the dose used in actual clinical research.
North Hollow does the opposite. Every ingredient is dosed at the level shown to work in human trials — the same milligram amounts published in peer-reviewed studies. No proprietary blends. No guesswork.
THE FOUR MECHANISM PATHWAYS
Most prostate symptoms in men over 45 come from a combination of four overlapping factors: DHT-driven prostate growth, chronic low-grade inflammation, reduced vascular flow, and weakened urinary muscle tone. North Hollow targets all four.
- HORMONE BALANCE
As men age, the conversion of testosterone to dihydrotestosterone (DHT) increases. DHT is the primary hormonal driver of prostate enlargement. Two ingredients target this pathway:
Saw Palmetto (320mg) — inhibits 5-alpha reductase, the enzyme that converts testosterone to DHT. Multiple meta-analyses of double-blind, placebo-controlled trials show improvements in urinary flow and nocturia at this dose.
Beta-Sitosterol (100mg) — a plant sterol that complements Saw Palmetto by binding to prostate tissue and reducing growth signaling. Clinical trials demonstrate significant improvement in IPSS (International Prostate Symptom Score) at 60-130mg daily.
2. INFLAMMATION CONTROL
Chronic inflammation in prostate tissue contributes to urinary symptoms and discomfort. Two of the most well-studied anti-inflammatory compounds:
Curcumin (400mg) — the active polyphenol in turmeric. Inhibits NF-kB and other inflammatory pathways. We use a bioavailability-enhanced form because standard curcumin has poor absorption.
Quercetin (400mg) — a flavonoid shown in clinical research to reduce chronic prostatitis symptoms. The Stanford prostatitis trial demonstrated significant symptom improvement at 500mg twice daily; we provide a meaningful daily dose to support that effect.
3. VASCULAR FLOW
Healthy prostate tissue needs healthy circulation. Two ingredients support this:
French Maritime Pine Bark (100mg) — standardized to 95% proanthocyanidins. Supports nitric oxide production and vascular function.
Grape Seed Extract (200mg) — rich in oligomeric proanthocyanidins (OPCs). Synergistic with pine bark for vascular support and antioxidant protection of prostate tissue.
4. URINARY FUNCTION
The final pathway addresses the muscle tone and tissue support of the bladder and urethra:
Pumpkin Seed Extract (300mg) — the German Commission E recognizes pumpkin seed for irritable bladder and BPH-related urinary symptoms. Clinical trials show improvements in IPSS and urinary flow at this dose.
Rye Pollen Extract (240mg) — known as Cernilton in research, this Swedish-developed extract has been studied for over 40 years for prostate health, with multiple randomized trials demonstrating efficacy.
SUPPORTING NUTRIENTS
Pygeum africanum (100mg) — traditional African herbal with modern clinical evidence for reducing nocturia and improving urinary flow.
Lycopene (20mg) — the antioxidant carotenoid concentrated in tomatoes. Multiple observational studies link higher lycopene intake to better prostate outcomes.
THIRD-PARTY TESTING
Every batch is tested by an independent ISO 17025-accredited lab for:
· Identity and potency of all active ingredients
· Heavy metals (lead, arsenic, cadmium, mercury)
· Microbial contamination
· Pesticide residues
Certificates of Analysis are available on request. Email hello@northhollow.com with your order number.
IMPORTANT NOTE
These statements have not been evaluated by the Food and Drug Administration. North Hollow is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take prescription medications, consult your doctor before starting any new supplement.